HCID 18633467, compound → HCID 18633448, compound

Participants

Reaction Steps

A solution of 7.3 g of trans-3'-O-acetyl-2',5'-dideoxy-5'-(ethoxycarbonylmethylene)-5-ethyluridine in 150 ml of ethanol was hydrogenated over 0.5 g of 10% palladium-on-carbon catalyst for 6 hours. The catalyst was removed by filtration and the filtrate was evaporated to dryness. The residue was recrystallized from ethanol to give 5.8 g of 3'-O-acetyl-2',5'-dideoxy-5'-(ethoxycarbonylmethyl)-5-ethyluridine in the form of a white solid of melting point 137°-138° C.

Provenance & Evidence