8-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-one → 8-{5-[4-(Pyrrolidin-1-yl)phenyl]oxazol-2-ylamino}-1,2,3,4-tetrahydronaphthalen-2-ol

HRID 2323828Notes

Reaction equation

HRID 2323828 reaction equation
[F:29][C:30]([F:31])([F:32])[c:33]1[cH:34][cH:35][c:36](-[c:37]2[o:38][c:39]([NH:40][c:41]3[cH:42][cH:43][cH:44][c:45]4[c:46]3[CH2:47][C:48](=[O:49])[CH2:50][CH2:51]4)[n:52][cH:53]2)[cH:54][cH:55]1.[N:1]1([c:6]2[cH:7][cH:8][c:9](-[c:12]3[cH:13][n:14][c:15]([NH:17][c:18]4[cH:19][cH:20][cH:21][c:22]5[c:27]4[CH2:26][C:25](=[O:28])[CH2:24][CH2:23]5)[o:16]3)[cH:10][cH:11]2)[CH2:2][CH2:3][CH2:4][CH2:5]1>>[N:1]1([c:6]2[cH:7][cH:8][c:9](-[c:12]3[cH:13][n:14][c:15]([NH:17][c:18]4[cH:19][cH:20][cH:21][c:22]5[c:27]4[CH2:26][CH:25]([OH:28])[CH2:24][CH2:23]5)[o:16]3)[cH:10][cH:11]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 119558408-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-oneHCID 672295858-{[5-(4-pyrrolidin-1-ylphenyl)-1,3-oxazol-2-yl]amino}-3,4-dihydronaphthalen-2(1H)-one

Product 1

HCID 119642608-{5-[4-(Pyrrolidin-1-yl)phenyl]oxazol-2-ylamino}-1,2,3,4-tetrahydronaphthalen-2-ol

Sources & evidence

ORD record
ord-95164666e965423a9de0692436358517
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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