Acetic Anhydride → HCID 18633398, compound

Participants

Reaction Steps

0.25 g of 5'-[2-(4-benzyloxy-2,6-dimethylphenyl)acetamido]-2',5'-dideoxy-5-ethyluridine was stirred as a slurry in 5 ml of dry pyridine with 0.4 ml of acetic anhydride for 72 hours. The resulting solution was evaporated in vacuo and the residue was re-evaporated three times with toluene. After trituration with diethyl ether and filtration there was obtained 0.22 g of crude product of melting point 188°-191° C. Recrystallization from a mixture of 4 ml of methylene chloride and 4 ml of petroleum ether gave 0.20 g of pure 3'-O-acetyl-5'-[2-(4-benzyloxy-2,6-dimethylphenyl)acetamido]-2',5'-dideoxy-5-ethyluridine of melting point 194°-196° C. (dec).

Provenance & Evidence