5'-Azido-2',5'-dideoxy-5-n-propyluridine → 5'-Amino-2',5'-dideoxy-5-n-propyluridine

Participants

Reaction Steps

0.38 g of 5'-azido-2',5'-dideoxy-5-n-propyluridine was dissolved in 100 ml of ethanol and the solution was hydrogenated in the presence of 0.1 g of 10% palladium-on-charcoal catalyst for 2 hours at room temperature and under atmospheric pressure. The catalyst was removed by filtration and the filtrate was evaporated to give 5'-amino-2',5'-dideoxy-5-n-propyluridine in the form of a solid which was used without further purification.

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