Hydrochloric Acid → HCID 67926647, compound

Participants

Reaction Steps

0.80 g of 5-acetyl-5'-azido-2',5'-dideoxyuridine was dissolved in 100 ml of methanol and 10 ml of 0.27M hydrogen chloride in methanol were added. 0.1 g of 5% palladium-on-charcoal catalyst was added as a slurry in ethanol and the mixture was hydrogenated for 3 hours at room temperature and under atmospheric pressure. The catalyst was removed by filtration and the filtrate was evaporated to give 0.91 g of hygro-scopic 5-acetyl-5'-amino-2',5'-dideoxyuridine hydrochloride of melting point 73°-85° C. (decomposition).

Provenance & Evidence