Tetrahydrofuran → (r)-4-Phenyl-2-oxazolidinone tetra n-butylammonium salt

Participants

Role	Name	HCID	Charge
Reactant	Tetrahydrofuran	HCID 8028	—
Reactant	Sodium hydride	HCID 24758	—
Reactant	(4R)-4-phenyl-1,3-oxazolidin-2-one	HCID 730425	—
Catalyst	Tetrabutylammonium Bromide	HCID 74236	—
Product	(r)-4-Phenyl-2-oxazolidinone tetra n-butylammonium salt	HCID 86752286	—

Reaction Steps

To a stirred solution of (R)-4-phenyl-2-oxazolidinone (174 mg, 1.06 mmol) in THF (4 mL) at 0° C., add NaH (4.3 mg, 60% emulsion in oil, 0.106 mmol). Allow the temperature to rise to room temperature over 30 min., then add tetra n-butylammonium bromide (34 mg, 0.106 mmol) to the mixture and stir for another 30 min. to obtain (R)-4-phenyl-2-oxazolidinone tetra n-butylammonium salt.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05728827
Source dataset	uspto-grants-1998_03
ORD ID	ord-b9cf0611d38749c6a169a2037a147be6
Source note	uspto-grants-1998_03