Sodium Bicarbonate → HCID 14537117, compound

Participants

Reaction Conditions

Reaction Steps

The 2-(12-tetrahydropyran-2-yloxydodeca-5,10-diynyl-1-(tetrahydropyran-2-yloxy)-4-methoxynaphthalene (0.396 g) is dissolved in 50% methanol/tetrahydrofuran (5 ml) and para-toluenesulfonic acid monohydrate (39 mg) is added. The mixture is heated to 60° C. for 35 minutes at which time TLC indicates complete reaction. After cooling, solid sodium bicarbonate is added, and the solvent is evaporated under reduced pressure. The residue is taken up in ethyl acetate and washed with water and brine, dried with magnesium sulfate, filtered, and concentrated to provide 0.335 g of a yellow oil.

Provenance & Evidence