N-[5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl]methanesulphonamide → 4-[(2,4-Dioxo-1,3-thiazolidin-5-yl)methyl]-N-(4-{4-[(2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidineyl}phenyl)benzenesulfonamide

HRID 2324107Notes

Reaction equation

HRID 2324107 reaction equation
[NH2:32][CH2:33][CH:34]([OH:35])[c:36]1[cH:37][cH:38][c:39]([OH:47])[c:40]([NH:42][S:43](=[O:44])(=[O:45])[CH3:46])[cH:41]1.[O:1]=[C:2]1[S:3][CH:4]([CH2:8][c:9]2[cH:10][cH:11][c:12]([S:15](=[O:16])(=[O:17])[NH:18][c:19]3[cH:20][cH:21][c:22]([N:25]4[CH2:26][CH2:27][C:28](=[O:31])[CH2:29][CH2:30]4)[cH:23][cH:24]3)[cH:13][cH:14]2)[C:5](=[O:7])[NH:6]1>>[O:1]=[C:2]1[S:3][CH:4]([CH2:8][c:9]2[cH:10][cH:11][c:12]([S:15](=[O:16])(=[O:17])[NH:18][c:19]3[cH:20][cH:21][c:22]([N:25]4[CH2:26][CH2:27][CH:28]([NH:32][CH2:33][CH:34]([OH:35])[c:36]5[cH:37][cH:38][c:39]([OH:47])[c:40]([NH:42][S:43](=[O:44])(=[O:45])[CH3:46])[cH:41]5)[CH2:29][CH2:30]4)[cH:23][cH:24]3)[cH:13][cH:14]2)[C:5](=[O:7])[NH:6]1

Participants

3

Reactant 2

HCID 9837752N-[5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl]methanesulphonamideHCID 222205034-(2,4-Dioxo-thiazolidin-5-ylmethyl)-N-[4-(4-oxo-piperidin-1-yl)-phenyl]-benzenesulfonamide

Product 1

HCID 222205484-[(2,4-Dioxo-1,3-thiazolidin-5-yl)methyl]-N-(4-{4-[(2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidineyl}phenyl)benzenesulfonamide

Sources & evidence

ORD record
ord-cf019ec60e964eea9bc09ed91b537baa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…