HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 3-(2-(7-Chloroquinolin-2-yl)cyclopropyl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2-(3-(2-(7-Chloroquinolin-2-yl)cyclopropyl)phenyl)1,3-dioxolane | HCID 10405721 | — |
| Solvent | AcOH THF water | HCID 21877175 | — |
| Product | 3-(2-(7-Chloroquinolin-2-yl)cyclopropyl)benzaldehyde | HCID 10447962 | — |
Reaction Steps
The dioxolane (step 3) (500 mg, 1.42 mmoles) was heated at reflux in 9 mL of THF:AcOH:H2O 6:2:1 for 2 hours. Addition of 25% NH4OAc, extraction with EtOAc, drying, evaporation, and flash chromatography on silica with EtOAc:toluene 2.5:97.5 afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04851409 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-10155f182a754488b8e0de3e30410c3c |
| Source note | uspto-grants-1989_07 |