反应详情

To the cyanide (Step 1, 10 g) in formic acid (200 mL) at 100° was added portionwise Ni-Al alloy (3 g). The reaction mixture was heated at 110° for 6 hrs, filtered and evaporated. The residue was partitioned between NaHCO3 (aq) and ethyl acetate, and the organic layer was dried and evaporated. Flash chromatography using 30% ether in hexane afforded the title compound.

1. temperatureThe reaction mixture was heated at 110° for 6 hrs
2. filtrationfiltered
3. customevaporated
4. customThe residue was partitioned between NaHCO3 (aq) and ethyl acetate
5. customthe organic layer was dried
6. customevaporated