4-Fluoropiperidine → N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-3-[2-(4-fluoropiperidin-1-yl)ethoxy]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

HRID 2324452Notes

Reaction equation

HRID 2324452 reaction equation
[Cl:1][CH2:2][CH2:3][O:4][c:5]1[n:6][nH:7][c:8]2[n:9][cH:10][n:11][c:12]([NH:14][c:15]3[cH:16][c:17]([Cl:29])[c:18]([O:21][CH2:22][c:23]4[n:24][cH:25][cH:26][cH:27][cH:28]4)[cH:19][cH:20]3)[c:13]12.[F:30][CH:31]1[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]1>>[CH2:2]([CH2:3][O:4][c:5]1[n:6][nH:7][c:8]2[n:9][cH:10][n:11][c:12]([NH:14][c:15]3[cH:16][c:17]([Cl:29])[c:18]([O:21][CH2:22][c:23]4[n:24][cH:25][cH:26][cH:27][cH:28]4)[cH:19][cH:20]3)[c:13]12)[N:34]1[CH2:33][CH2:32][CH:31]([F:30])[CH2:36][CH2:35]1

Participants

3

Reactant 2

HCID 27591594-FluoropiperidineHCID 115028913-(2-chloroethoxy)-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product 1

HCID 11504233N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-3-[2-(4-fluoropiperidin-1-yl)ethoxy]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Sources & evidence

ORD record
ord-91ddc8db5e994461a7b78932906c2569
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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