反应详情

In 6.5 ml of chloroform was dissolved 650 mg of methyl 6-(3-amino-1-pyrrolidinyl)-2-(2,4-difluorophenylamino)-5-fluoronicotinate, and 190 mg of acetic anhydride was added to the resulting solution, after which the resulting mixture was subjected to reaction at room temperature for 10 minutes. The solvent was then removed by distillation under reduced pressure. To the crystalline material thus obtained was added 2 ml of diethyl ether, after which crystals were collected by filtration to obtain 720 mg (yield 99.4%) of methyl 6-(3-acetylamino-1-pyrrolidinyl)-2-(2,4-difluorophenylamino)-5-fluoronicotinate having a melting point of 199°-200° C.

1. additionwas added to the resulting solution
2. customafter which the resulting mixture was subjected to reaction at room temperature for 10 minutes
3. customThe solvent was then removed by distillation under reduced pressure
4. customTo the crystalline material thus obtained
5. filtrationafter which crystals were collected by filtration