Dimethyl Sulfoxide → Ethyl 2,2-difluoro-2-(p-tolyl)acetate

HRID 2324573Notes

Reaction equation

HRID 2324573 reaction equation
[Br:9][C:10]([C:11](=[O:12])[O:13][CH2:14][CH3:15])([F:16])[F:17].[C:29]([O:30][CH:31]([CH3:32])[CH3:33])(=[O:34])[CH3:35].[CH3:25][S:26]([CH3:27])=[O:28].[Cu:37].[I:1][c:2]1[cH:3][cH:4][c:5]([CH3:8])[cH:6][cH:7]1.[K+:23].[K+:24].[OH2:36].[P:18]([O-:19])([O-:20])([OH:21])=[O:22]>>[c:2]1([C:10]([C:11](=[O:12])[O:13][CH2:14][CH3:15])([F:16])[F:17])[cH:3][cH:4][c:5]([CH3:8])[cH:6][cH:7]1

Participants

9

Reactant 8

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 962WaterHCID 7915Isopropyl AcetateHCID 122074-IodotolueneHCID 23978CopperHCID 69585Ethyl bromodifluoroacetateHCID 3681305Hydrogen phosphate

Product 1

HCID 14888699Ethyl 2,2-difluoro-2-(p-tolyl)acetate

Sources & evidence

ORD record
ord-559fab15d32947489224d3154c331cc4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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