Benzonitrile, 3-(bromomethyl)- → tert-butyl (3RS,4RS)-4-[4-(3-cyano-benzyloxy)-phenyl]-3-(1,4-dimethoxy-naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

HRID 2324594Notes

Reaction equation

HRID 2324594 reaction equation
[Br:37][CH2:38][c:39]1[cH:40][c:41]([C:42]#[N:43])[cH:44][cH:45][cH:46]1.[CH3:1][O:2][c:3]1[c:4]([CH2:15][O:16][CH:17]2[CH2:18][N:19]([C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:20][CH2:21][CH:22]2[c:23]2[cH:24][cH:25][c:26]([OH:29])[cH:27][cH:28]2)[cH:5][c:6]([O:13][CH3:14])[c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]12>>[CH3:1][O:2][c:3]1[c:4]([CH2:15][O:16][CH:17]2[CH2:18][N:19]([C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:20][CH2:21][CH:22]2[c:23]2[cH:24][cH:25][c:26]([O:29][CH2:38][c:39]3[cH:40][c:41]([C:42]#[N:43])[cH:44][cH:45][cH:46]3)[cH:27][cH:28]2)[cH:5][c:6]([O:13][CH3:14])[c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]12

Participants

3

Reactant 2

HCID 97249Benzonitrile, 3-(bromomethyl)-HCID 54373685tert-butyl (3RS,4RS)-3-(1,4-dimethoxy-naphthalen-2-ylmethoxy)-4-(4-hydroxy-phenyl)-piperidine-1-carboxylate

Product 1

HCID 86604541tert-butyl (3RS,4RS)-4-[4-(3-cyano-benzyloxy)-phenyl]-3-(1,4-dimethoxy-naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-1a7c31782ebf4034be69488bcb06d8c8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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