Chloroform → Laquinimod

HRID 2324729Notes

Reaction equation

HRID 2324729 reaction equation
[CH2:1]([CH3:2])[NH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[CH:48]([Cl:49])([Cl:50])[Cl:51].[Cl:10][P:11]([Cl:12])([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)([c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1.[OH:31][c:32]1[c:33]([C:45](=[O:46])[OH:47])[c:34](=[O:44])[n:35]([CH3:43])[c:36]2[cH:37][cH:38][cH:39][c:40]([Cl:42])[c:41]12>>[CH2:1]([CH3:2])[N:3]([c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[C:45]([c:33]1[c:32]([OH:31])[c:41]2[c:36]([n:35]([CH3:43])[c:34]1=[O:44])[cH:37][cH:38][cH:39][c:40]2[Cl:42])=[O:46]

Participants

5

Reactant 4

HCID 6212ChloroformHCID 7670N-EthylanilineHCID 260420Triphenylphosphine dichlorideHCID 547202275-Chloro-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

Product 1

HCID 54677946Laquinimod

Sources & evidence

ORD record
ord-1ac5fd89243943909898f3048796db78
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…