Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | HCID 21996901 | HCID 21996901 | — |
| Product | HCID 86747119 | HCID 86747119 | — |
Reaction Steps
1.9 g (0.0417 mol) of gaseous dimethylamine were passed into a mixture of 8.9 g (0.0417 mol) of 2-amino-4-chlorodifluoromethoxy-6-fluoropyrimidine in 100 ml of tetrahydrofuran in the course of 10 minutes while stirring at 0° C. Stirring was continued for 1 hour at 0° C. and for 2 hours at 25° C. Conventional working up gave 9.7 g (97.5% of theory) of the title compound of melting point 127°-130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05591694 |
|---|
| Source dataset | uspto-grants-1997_01 |
|---|
| ORD ID | ord-809d4d6e22aa4d368b5250333a9fa17c |
|---|
| Source note | uspto-grants-1997_01 |
|---|
