1,2,4-Triazine-3,5(2H,4H)-dione → 2-acetyl-6-bromo-2H-[1,2,4]triazine-3,5-dione

Participants

Reaction Steps

The 6-bromo-3,5-dioxo-(2H,4H)-1,2,4-triazine (5 g) obtained from the 3,5-dioxo-(2H,4H)-1,2,4-triazine in accordance with the technique described in example 1b is treated with acetic anhydride (50 ml) for 7 hours under reflux. After concentration to dryness under vacuum and taking up in ethyl ether, the precipitate is filtered, centrifuged, and dried under vacuum at 50° C. to give compound 15a (4.6 g).

Provenance & Evidence