Nitric Acid → HCID 135515411, compound

Participants

Reaction Steps

A stirred solution of 2-(2-ethoxyphenyl)-pyrido[3,2-d]pyrimidin-4(3H)-one (Preparation 10; 1.4 g, 0.0052 mol)in concentrated sulphuric acid (11 ml) at 0° C., was treated dropwise with concentrated nitric acid (0.4 ml). The reaction mixture was allowed to warm to ambient temperature, stirred for a further 18 hours, then added dropwise to ice/water (70 g). The resulting precipitate was collected by filtration, dried under vacuum and then crystallised from acetonitrile to give the title compound as a pale yellow solid (0.22 g, 86%), m.p. 251°-254° C. Found: C,57.69; H,3.87; N,17.94. C15H12N4O4 requires C,57.41; H,3.82; N,18.37%.

Provenance & Evidence