2-Propanesulfonyl chloride → HCID 135985185, compound

HRID 232566Notes

Reaction equation

HRID 232566 reaction equation
[CH3:1][CH:2]([S:4](Cl)(=[O:6])=[O:5])[CH3:3].[NH2:8][C:9]1[CH:10]=[CH:11][C:12]([O:26][CH2:27][CH3:28])=[C:13]([C:15]2[NH:16][C:17](=[O:25])[C:18]3[N:24]=[CH:23][CH:22]=[CH:21][C:19]=3[N:20]=2)[CH:14]=1>>[CH2:27]([O:26][C:12]1[CH:11]=[CH:10][C:9]([NH:8][S:4]([CH:2]([CH3:3])[CH3:1])(=[O:6])=[O:5])=[CH:14][C:13]=1[C:15]1[NH:16][C:17](=[O:25])[C:18]2[N:24]=[CH:23][CH:22]=[CH:21][C:19]=2[N:20]=1)[CH3:28]

Participants

3

Reactant 2

HCID 824082-Propanesulfonyl chlorideHCID 135482279HCID 135482279, compound

Product 1

HCID 135985185HCID 135985185, compound

Procedure

The title compound was prepared using 2-propyl-sulphonyl chloride and 2-(5-amino-2-ethoxyphenyl)-pyrido[3,2-d]pyrimidin-4(3H)-one (Example 20), following the procedure of Example 12, and was obtained as a hydrated solid (59%), m.p. 211°-213° C. Found: C,54.98; H,5.07; N;14.21. C18H20N4O4S;0.25 H2O requires C,55.02; H,5.26; N,14.26%.

Sources & evidence

ORD record
ord-8f0acd88f72741f0a7fb8f14edc357d7
Source dataset
uspto-grants-1997_01
Patent number
US05591742

Reaction notes

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