Water → Methyl 5-[(6-cyclopentyl-6-{2-[4-(difluoromethyl)-3-fluorophenyl]ethyl}-4-hydroxy-2-oxo-5,6-dihydro-2H-pyran-3-yl)methyl]isoxazol-3-ylcarbamate
Reaction equation
[Br:1][CH2:2][c:3]1[cH:4][c:5]([NH:8][C:9]([O:10][CH3:11])=[O:12])[n:6][o:7]1.[CH:22]1([C:27]2([CH2:35][CH2:36][c:37]3[cH:38][c:39]([F:46])[c:40]([CH:43]([F:44])[F:45])[cH:41][cH:42]3)[CH2:28][C:29](=[O:34])[CH2:30][C:31](=[O:33])[O:32]2)[CH2:23][CH2:24][CH2:25][CH2:26]1.[Cl:13][CH2:14][c:15]1[n:16]([CH3:17])[n:18][c:19]([CH3:20])[n:21]1.[OH2:47]>>[CH2:2]([c:3]1[cH:4][c:5]([NH:8][C:9]([O:10][CH3:11])=[O:12])[n:6][o:7]1)[C:30]1=[C:29]([OH:34])[CH2:28][C:27]([CH:22]2[CH2:23][CH2:24][CH2:25][CH2:26]2)([CH2:35][CH2:36][c:37]2[cH:38][c:39]([F:46])[c:40]([CH:43]([F:44])[F:45])[cH:41][cH:42]2)[O:32][C:31]1=[O:33]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-76139c28c87b402abb4e0a97b43fe8b3
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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