反应详情

温度

0 °C

To 2,3,6-trifluoro-4-chlorotoluene (0.22 g) is added conc. sulfuric acid (3 ml) and the mixture is cooled to 0° C. Thereto potassium nitrate (0.18 g) is added and the mixture is stirred for 15 minutes under ice-cooling. The reaction mixture is poured into ice-water, extracted with dichloromethane, and the extract is washed with a saturated aqueous solution of sodium hydrogen carbonate, then with water and dried. The solvent is distilled off under reduced pressure to give 2,3,6-trifluoro-4-chloro-5-nitrotoluene (0.17 g).

1. temperaturecooling
2. extractionextracted with dichloromethane
3. washthe extract is washed with a saturated aqueous solution of sodium hydrogen carbonate
4. dry with materialwith water and dried
5. distillationThe solvent is distilled off under reduced pressure