Chloroform → 2-fluoro-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)nicotinamide

HRID 2326791Notes

Reaction equation

HRID 2326791 reaction equation
[Cl:57][CH:58]([Cl:59])[Cl:60].[F:1][c:2]1[n:3][cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])[OH:10].[NH2:35][c:36]1[cH:37][cH:38][c:39]([O:40][c:41]2[n:42][cH:43][cH:44][cH:45][c:46]2-[c:47]2[n:48][c:49]([NH:53][CH3:54])[n:50][cH:51][cH:52]2)[cH:55][cH:56]1.[P-:11]([F:12])([F:13])([F:14])([F:15])([F:16])[F:17].[n:18]1([O:19][C:20]([N:21]([CH3:22])[CH3:23])=[N+:24]([CH3:25])[CH3:26])[c:27]2[n:28][cH:29][cH:30][cH:31][c:32]2[n:33][n:34]1>>[F:1][c:2]1[n:3][cH:4][cH:5][cH:6][c:7]1[C:8](=[O:10])[NH:35][c:36]1[cH:37][cH:38][c:39]([O:40][c:41]2[n:42][cH:43][cH:44][cH:45][c:46]2-[c:47]2[n:48][c:49]([NH:53][CH3:54])[n:50][cH:51][cH:52]2)[cH:55][cH:56]1

Participants

6

Reactant 5

HCID 6212ChloroformHCID 9886HexafluorophosphateHCID 960892-Fluoronicotinic acidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 469295414-(2-(4-aminophenoxy)pyridin-3-yl)-N-methylpyrimidin-2-amine

Product 1

HCID 669706302-fluoro-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)nicotinamide

Sources & evidence

ORD record
ord-bcca470f15644cc48d648615108fb3b5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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