Chloroacetyl chloride → 5-Chloroacetyl-8-methoxy-3,4-dihydrocarbostyril

HRID 232705Notes

Reaction equation

[Cl:1][CH2:2][C:3](Cl)=[O:4].[CH3:6][O:7][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:17]=1[NH:16][C:15](=[O:18])[CH2:14][CH2:13]2>>[Cl:1][CH2:2][C:3]([C:11]1[CH:10]=[CH:9][C:8]([O:7][CH3:6])=[C:17]2[C:12]=1[CH2:13][CH2:14][C:15](=[O:18])[NH:16]2)=[O:4]

Participants

Reactant 2

HCID 6577Chloroacetyl chloride

HCID 133754763,4-Dihydro-8-methoxy-2(1H)-quinolinone

Product 1

HCID 135332315-Chloroacetyl-8-methoxy-3,4-dihydrocarbostyril

Procedure

By using chloroacetyl chloride and 8-methoxy-3,4-dihydrocarbostyril, there was obtained 5-chloroacetyl-8-methoxy-3,4-dihydrocarbostyril as a white powder having a melting point of 187°-188° C.

Sources & evidence

ORD record: ord-fd006a81129641bda8e1a61295dc5466
Source dataset: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05591751

Reaction notes

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