HCID 10857784, compound → HCID 23359069, compound

Participants

Reaction Steps

0.12 g of 10% Pd-C was added to 20 ml of an acetic acid solution containing 1.20 g of 8-methoxy-6-ethoxycarbonylcarbostyril. The mixture was subjected to hydrogenation at 90° C. at normal pressure for 1 hour. The catalyst in the reaction mixture was removed by filtration. The filtrate was subjected to distillation to remove the solvent. The residue was purified by a silica gel column chromatography (elutant: chloroform) and recrystallized from chloroform-diethyl ether to obtain 0.85 g of 8-methoxy-6-ethoxycarbonyl-3,4-dihydrocarbostyril as a white powder.

Provenance & Evidence