Methanol → HCID 11807058, compound

HRID 232712Notes

Reaction equation

HRID 232712 reaction equation
S(Cl)(Cl)=O.[N+:5]([C:8]1[CH:9]=[C:10]([C:19]([OH:21])=[O:20])[CH:11]=[C:12]2[C:17]=1[NH:16][C:15](=[O:18])[CH2:14][CH2:13]2)([O-:7])=[O:6].[CH3:22]O>>[N+:5]([C:8]1[CH:9]=[C:10]([C:19]([O:21][CH3:22])=[O:20])[CH:11]=[C:12]2[C:17]=1[NH:16][C:15](=[O:18])[CH2:14][CH2:13]2)([O-:7])=[O:6]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 11053632HCID 11053632, compound

Product 1

HCID 11807058HCID 11807058, compound

Procedure

7 ml of thionyl chloride was added to a solution of 15 g of 8-nitro-6-carboxy-3,4-dihydrocarbostyril in 150 ml of methanol with ice-cooling. The mixture was refluxed by heating, for 3 hours. The reaction mixture was concentrated under reduced pressure. The residue was recrystallized from methanol to obtain 12.8 g of 8-nitro-6-methoxycarbonyl-3,4-dihydrocarbostyril as a light yellow powder.

Workup

  1. temperaturecooling
  2. temperatureThe mixture was refluxed
  3. temperatureby heating, for 3 hours
  4. concentrationThe reaction mixture was concentrated under reduced pressure
  5. customThe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-269203a77aa34de7940f29fa5d63fb0a
Source dataset
uspto-grants-1997_01
Patent number
US05591751

Reaction notes

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