Benzoyl Peroxide → 8-Nitro-6-methoxycarbonylcarbostyril

Participants

Reaction Steps

10.7 g of N-bromosuccinimide and a catalytic amount of benzoyl peroxide were added to a solution of 2 g of 8-nitro-6-methoxycarbonyl-3,4-dihydrocarbostyril in 200 ml of chloroform. The mixture was refluxed by heating, for 4 hours. Thereto was added an additional amount (5.0 g) of N-bromosuccinimide. The resulting mixture was refluxed by heating, for 1 hour. The reaction mixture was concentrated under reduced pressure. The residue was recrystallized from ethanol two times to obtain 7.1 g of 8-nitro-6-methoxycarbonylcarbostyril as light yellow needles.

Provenance & Evidence