HCID 23359081, compound → HCID 23359105, compound

Participants

Reaction Steps

150 mg of 10% palladium-carbon was added to 11 g of 4-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinyl}carbonyl-2-benzyloxyquinoline (obtained in Reference Example 2) in 20 ml of ethanol. The mixture was stirred at room temperature at a hydrogen pressure of 1 atm. for 1 hour. The reaction mixture was filtered to remove the catalyst. The filtrate was concentrated under reduced pressure. The residue was crystallized from diethyl ether and then re- crystallized from ligroin-ethyl acetate to obtain 0.3 g of 4-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinyl}carbonylcarbostyril as a white powder having a melting point of 155°-158° C.

Provenance & Evidence