反应详情

0.5 g of 5% palladium-carbon was suspended in 0 ml of ethanol. Thereto was added 5 g of 8-nitro-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril. The mixture was subjected to catalytic reduction at 30°-40° C. at normal pressure in a water bath. After the completion of hydrogen absorption, the reaction mixture was filtered to remove the catalyst. The catalyst was washed with ethanol. The filtrate and the washings were mixed. The mixture was subjected to distillation to remove the solvent to obtain 4.6 g of 8-amino-6-{4-[N-methyl-N-(2-phenylethyl)amino]-1-piperidinylcarbonyl}-3,4-dihydrocarbostyril as a white amorphous.

1. customThe mixture was subjected to catalytic reduction at 30°-40° C. at normal pressure in a water bath
2. customAfter the completion of hydrogen absorption
3. filtrationthe reaction mixture was filtered
4. customto remove the catalyst
5. washThe catalyst was washed with ethanol
6. additionThe filtrate and the washings were mixed
7. distillationThe mixture was subjected to distillation
8. customto remove the solvent