Pyridine → 1,1-Dimethylethyl 4-[5-(2-chloro-4-pyrimidinyl)-4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-2-yl]-1-piperidinecarboxylate
Reaction equation
[F:34][c:35]1[c:36]([S:42](=[O:43])(=[O:44])[Cl:45])[c:37]([F:41])[cH:38][cH:39][cH:40]1.[NH2:1][c:2]1[c:3]([F:33])[c:4](-[c:8]2[n:9][c:10]([CH:20]3[CH2:21][CH2:22][N:23]([C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:24][CH2:25]3)[s:11][c:12]2-[c:13]2[n:14][c:15]([Cl:19])[n:16][cH:17][cH:18]2)[cH:5][cH:6][cH:7]1.[cH:46]1[cH:47][cH:48][n:49][cH:50][cH:51]1>>[NH:1]([c:2]1[c:3]([F:33])[c:4](-[c:8]2[n:9][c:10]([CH:20]3[CH2:21][CH2:22][N:23]([C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:24][CH2:25]3)[s:11][c:12]2-[c:13]2[n:14][c:15]([Cl:19])[n:16][cH:17][cH:18]2)[cH:5][cH:6][cH:7]1)[S:42]([c:36]1[c:35]([F:34])[cH:40][cH:39][cH:38][c:37]1[F:41])(=[O:43])=[O:44]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-b42a90aced1b45de92454b4f75f67f02
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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