1,4-Dioxane → 2-[4-(4-Ureido-phenyl)-thiazol-2-yl carbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

HRID 2327380Notes

Reaction equation

HRID 2327380 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH:12]([C:16]([NH:17][c:18]2[s:19][cH:20][c:21](-[c:23]3[cH:24][cH:25][c:26]([NH2:29])[cH:27][cH:28]3)[n:22]2)=[O:30])[CH2:13][CH2:14][CH2:15]1.[O:38]1[CH2:39][CH2:40][O:41][CH2:42][CH2:43]1.[Si:31]([CH3:32])([CH3:33])([CH3:34])[N:35]=[C:36]=[O:37]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH:12]([C:16]([NH:17][c:18]2[s:19][cH:20][c:21](-[c:23]3[cH:24][cH:25][c:26]([NH:29][C:36]([NH2:35])=[O:37])[cH:27][cH:28]3)[n:22]2)=[O:30])[CH2:13][CH2:14][CH2:15]1

Participants

4

Reactant 3

HCID 312751,4-DioxaneHCID 70696Trimethylsilyl isocyanateHCID 57849733Benzyl 2-[[4-(4-aminophenyl)-1,3-thiazol-2-yl]carbamoyl]pyrrolidine-1-carboxylate

Product 1

HCID 591409232-[4-(4-Ureido-phenyl)-thiazol-2-yl carbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

Sources & evidence

ORD record
ord-032c006b527640049f29de493bb14a3c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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