Water → 7-Bromo-1-(trans-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

HRID 2327397Notes

Reaction equation

HRID 2327397 reaction equation
[Br:1][c:2]1[n:3][c:4]([NH:15][CH:16]2[CH2:17][CH2:18][CH:19]([O:22][CH3:23])[CH2:20][CH2:21]2)[c:5]([NH:8][CH2:9][C:10](=[O:11])[O:12][CH2:13][CH3:14])[n:6][cH:7]1.[OH2:24].[P:25](=[O:26])([OH:27])([OH:28])[OH:29]>>[Br:1][c:2]1[n:3][c:4]2[c:5]([n:6][cH:7]1)[NH:8][CH2:9][C:10](=[O:11])[N:15]2[CH:16]1[CH2:17][CH2:18][CH:19]([O:22][CH3:23])[CH2:20][CH2:21]1

Participants

4

Reactant 3

HCID 962WaterHCID 1004Phosphoric AcidHCID 86293006Ethyl 2-(5-bromo-3-(trans-4-methoxycyclohexylamino)pyrazin-2-ylamino)acetate

Product 1

HCID 862930057-Bromo-1-(trans-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

Sources & evidence

ORD record
ord-b991f59b3b0747cd97db1b83ee554398
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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