HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-bromo-2,5-dichlorothiophene-3-sulfonyl chloride → N-(4-Bromo-3-methyl-5-isoxazolyl)-2,5-dichloro-4-bromothiophene-3-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-bromo-2,5-dichlorothiophene-3-sulfonyl chloride | HCID 519295 | — |
| Reactant | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| Product | N-(4-Bromo-3-methyl-5-isoxazolyl)-2,5-dichloro-4-bromothiophene-3-sulfonamide | HCID 15342067 | 58% |
Reaction Steps
N-(4-Bromo-3-methyl-5-isoxazolyl)-2,5-dichloro-4-bromothiophene-3-sulfonamide was prepared in the same manner as described in Example 1 from 5-amino-4-bromo-3-methylisoxazole and 4-bromo-2,5-dichlorothiophene-3-sulfonyl chloride in 58% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 146°-149° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05591761 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-dc92166e21594a9397666548bda48ccb |
| Source note | uspto-grants-1997_01 |