Quinolin-6-ylboronic Acid (contains varying amounts of Anhydride) → 5-(4-Fluoro-3-quinolin-6-ylphenyl)-2-trifluoromethyl[1,8]naphthyridine

HRID 2327494Notes

Reaction equation

HRID 2327494 reaction equation
[F:1][c:2]1[c:3]([O:22][S:23]([C:24]([F:25])([F:26])[F:27])(=[O:28])=[O:29])[cH:4][c:5](-[c:8]2[cH:9][cH:10][n:11][c:12]3[n:13][c:14]([C:18]([F:19])([F:20])[F:21])[cH:15][cH:16][c:17]23)[cH:6][cH:7]1.[n:30]1[cH:31][cH:32][cH:33][c:34]2[cH:35][c:36]([B:40]([OH:41])[OH:42])[cH:37][cH:38][c:39]12>>[F:1][c:2]1[c:3](-[c:36]2[cH:35][c:34]3[cH:33][cH:32][cH:31][n:30][c:39]3[cH:38][cH:37]2)[cH:4][c:5](-[c:8]2[cH:9][cH:10][n:11][c:12]3[n:13][c:14]([C:18]([F:19])([F:20])[F:21])[cH:15][cH:16][c:17]23)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 4192671Quinolin-6-ylboronic Acid (contains varying amounts of Anhydride)HCID 86594178Trifluoromethanesulfonic acid 2-fluoro-5-(7-trifluoromethyl[1,8]naphthyridin-4-yl)phenyl ester

Product 1

HCID 102022045-(4-Fluoro-3-quinolin-6-ylphenyl)-2-trifluoromethyl[1,8]naphthyridine

Sources & evidence

ORD record
ord-3ffe60ee46bb4446a8a413c868f9f6da
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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