1,4-Dioxa-8-azaspiro(4.5)decane → HCID 67684451, compound

HRID 232773Notes

Reaction equation

HRID 232773 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([C@H:11]3[CH2:16][C@H:15]4[C@H:17]5[C@H:27]([CH2:28][CH2:29][C@:13]4([CH3:14])[C@H:12]3[OH:31])[C@:25]3([CH3:26])[C@H:20]([CH2:21][C@@H:22]4[O:30][C@@H:23]4[CH2:24]3)[CH2:19][CH2:18]5)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[O:32]1[C:36]2([CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)[O:35][CH2:34][CH2:33]1>>[O:32]1[C:36]2([CH2:41][CH2:40][N:39]([C@H:23]3[CH2:24][C@@:25]4([CH3:26])[C@@H:20]([CH2:19][CH2:18][C@@H:17]5[C@@H:27]4[CH2:28][CH2:29][C@@:13]4([CH3:14])[C@H:15]5[CH2:16][C@H:11]([N:8]5[CH2:9][CH2:10][C:5]6([O:1][CH2:2][CH2:3][O:4]6)[CH2:6][CH2:7]5)[C@@H:12]4[OH:31])[CH2:21][C@@H:22]3[OH:30])[CH2:38][CH2:37]2)[O:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 86750121HCID 86750121, compound

Product 1

HCID 67684451HCID 67684451, compoundYield 80.1%

Procedure

16β-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-2α,3α-epoxy-17β-hydroxy-5α-androstane is reacted with 1,4-dioxa-8-azaspiro[4.5]decane as described in Example 3 to obtain the title compound in a yield of 80.1%, m.p.: 180°-182° C.

Sources & evidence

ORD record
ord-edba8d50f0974314ae4322d7150304c6
Source dataset
uspto-grants-1997_01
Patent number
US05591735

Reaction notes

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