Sodium borohydride → HCID 86750123, compound

HRID 232775Notes

Reaction equation

[O:1]1[C@H:3]2[CH2:4][C@H:5]3[C@:18]([CH3:20])([CH2:19][C@@H:2]12)[C@@H:17]1[C@H:8]([C@H:9]2[C@@:13]([CH2:15][CH2:16]1)([CH3:14])[C:12](=[O:21])[C@@H:11]([N:22]1[CH2:27][CH2:26][CH:25]([OH:28])[CH2:24][CH2:23]1)[CH2:10]2)[CH2:7][CH2:6]3.[BH4-].[Na+]>>[O:1]1[C@H:3]2[CH2:4][C@H:5]3[C@:18]([CH3:20])([CH2:19][C@@H:2]12)[C@@H:17]1[C@H:8]([C@H:9]2[C@@:13]([CH2:15][CH2:16]1)([CH3:14])[C@@H:12]([OH:21])[C@@H:11]([N:22]1[CH2:27][CH2:26][CH:25]([OH:28])[CH2:24][CH2:23]1)[CH2:10]2)[CH2:7][CH2:6]3

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 86750124HCID 86750124, compound

Product 1

HCID 86750123HCID 86750123, compoundYield 86.06%

Procedure

2α,3α-Epoxy-16β-(4-hydroxy-1-piperidinyl)-5α-androstane-17-one is reduced by using sodium borohydride as described in Example 2 to give the title product in a yield of 86.06%, m.p.: 204°-206° C.

Sources & evidence

ORD record: ord-051749776e74474480cf93ebd97114ad
Source dataset: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05591735

Reaction notes

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