HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allyl bromide → 1-[3alpha,17beta-Dihydroxy-2beta-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-5alpha-androstane-16beta-yl]-1-(2-propenyl)pyrrolidinium bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allyl bromide | HCID 7841 | — |
| Reactant | 2beta-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-16beta-(1-pyrrolidinyl)-5alpha-androstane-3alpha,17beta-diol | HCID 22868545 | — |
| Product | 1-[3alpha,17beta-Dihydroxy-2beta-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-5alpha-androstane-16beta-yl]-1-(2-propenyl)pyrrolidinium bromide | HCID 67684035 | 82% |
Reaction Steps
2β-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-16β-(1-pyrrolidinyl)-5α-androstane-3α,17β-diol is reacted with allyl bromide as described in Example 5 to obtain the title compound in a yield of 82%, m.p.: 238°-240° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05591735 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-f08f0ff41dae412ea28d0eb683bd7670 |
| Source note | uspto-grants-1997_01 |