反应详情

To a solution of 11 g (45.2 mmol) of N-[2-(7-methoxynaphth-1-yl)ethyl]acetamide and 7.7 g (57.7 mmol) of AlCl3 in 60 cm3 of nitrobenzene, add dropwise 57.9 mmol of benzoyl chloride, at 12° C. and under nitrogen. Allow to react for 2 hours at 12° C. and pour the reaction mixture onto ice. Extract with dichloromethane, dry over magnesium sulfate, concentrate and then chromatograph the crude material on silica (eluent CH2Cl2 /CH3OH: 99/1).

1. customat 12° C.
2. customto react for 2 hours at 12° C.
3. additionpour the reaction mixture onto ice
4. extractionExtract with dichloromethane
5. dry with materialdry over magnesium sulfate
6. concentrationconcentrate