huagongshe.com
HRID232791

反应详情

EQUATION

反应方程式

HRID 232791 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID8955

Pregnenolone

C21H32O2

结构：[H][H]
HCID178418361

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
HCID92787

3-beta-Hydroxy-5-alpha-pregnan-20-one

C21H34O2

收率 96.2%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of 3β-hydroxy-5-pregnen-20-one (980 mg, 316.5 g/m, 3.1 mmol) and 50 mg of 5% Pd/C in 50 mL of absolute ethyl alcohol was stirred under 1 atmosphere of hydrogen gas for 5 hours at room temperature. The reaction was filtered through a celite pad and the filtrate evaporated under reduced pressure to give 950 mg of 3β-hydroxy-5α-pregnan-20-one (96% yield).

WORKUP

后处理

  1. filtrationThe reaction was filtered through a celite pad
  2. customthe filtrate evaporated under reduced pressure