反应详情

To a stirred solution of 3α-hydroxy-5α-pregnan-20-one (3.2g, 318.5 g/m, 10 mmol) in 160 mL of methanol and 30 mL of dichloromethane at room temperature was slowly added sodium borohydride (3.3 g, 37.8 g/m, 87 mmol) over a period of 2 h. The mixture was stirred for an additional hour and then poured into ice cold water (700 mL) and extracted three times with ether. The combined organic phase was washed several times with water, dried over magnesium sulfate and concentrated to a white solid (2.35 g, 320.5 g/m, 7.3 mmol, 73%).

1. customat room temperature
2. customof 2 h
3. extractionextracted three times with ether
4. washThe combined organic phase was washed several times with water
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated to a white solid (2.35 g, 320.5 g/m, 7.3 mmol, 73%)