HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → Ganaxolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3alpha-Hydroxy-3beta-methyl-20,20-ethylenedioxy-5alpha-pregnane | HCID 69567598 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Ganaxolone | HCID 6918305 | — |
Reaction Steps
A solution of 3α-hydroxy-3β-methyl-20,20-ethylenedioxy-5α-pregnane and p-toluene sulfonic acid (catalytic) in wet acetone was heated at reflux overnight. The reaction was concentrated in vacuo and taken up in chloroform. The organic phase was washed with sodium bicarbonate, dried over magnesium sulfate, concentrated, and recrystallized from methanol to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05591733 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-a9b4df4c0ba94948b1675836eb12dec9 |
| Source note | uspto-grants-1997_01 |