Water → N-[2,3-dihydro-5-(2,6-dimethoxy-4-methylphenyl)-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]-1H-2-indolecarboxamide

HRID 2328488Notes

Reaction equation

HRID 2328488 reaction equation
[Cl:48][CH2:49][Cl:50].[NH2:23][CH:24]1[C:25](=[O:47])[N:26]([CH3:46])[c:27]2[c:28]([cH:42][cH:43][cH:44][cH:45]2)[C:29]([c:31]2[c:32]([O:40][CH3:41])[cH:33][c:34]([CH3:39])[cH:35][c:36]2[O:37][CH3:38])=[N:30]1.[OH2:51].[S:7]([Cl:8])([Cl:9])=[O:10].[cH:1]1[cH:2][cH:3][n:4][cH:5][cH:6]1.[nH:11]1[c:12]([C:20](=[O:21])[OH:22])[cH:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]12>>[nH:11]1[c:12]([C:20](=[O:22])[NH:23][CH:24]2[C:25](=[O:47])[N:26]([CH3:46])[c:27]3[c:28]([cH:42][cH:43][cH:44][cH:45]3)[C:29]([c:31]3[c:32]([O:40][CH3:41])[cH:33][c:34]([CH3:39])[cH:35][c:36]3[O:37][CH3:38])=[N:30]2)[cH:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]12

Participants

7

Reactant 6

HCID 962WaterHCID 1049PyridineHCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 72899Indole-2-carboxylic acidHCID 153796223-Amino-1,3-dihydro-5-(2,6-dimethoxy-4-methylphenyl)-1-methyl-1,4-benzodiazepin-2-one

Product 1

HCID 9805268N-[2,3-dihydro-5-(2,6-dimethoxy-4-methylphenyl)-1-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]-1H-2-indolecarboxamide

Sources & evidence

ORD record
ord-d64052cc7b624bcf857e45ca25ccc2e6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…