Ethanol → HCID 23359122, compound

Participants

Reaction Steps

20 ml of a 1N-sodium hydroxide aqueous solution was added to 0.4 g of 11-[2-(4-cyanophenylsulfonylamino)ethylthio]-2-(quinolin-2-yl)methoxy-6,11-dihydrodibenz[b,e]oxepine obtained in Example 34 suspended in 5 ml of ethanol and the mixture was refluxed under heating for 6 hours. After completion of the reaction, the solvent was removed, water was added to the residue, insolubles were removed by filtration and then the residue was adjusted to about pH 3 with 1N-hydrochloric acid. Crystals precipitated were collected by filtration and dissolved in ethyl acetate and the organic layer was washed with a saturated saline solution, dried over anhydrous sodium sulfate and condensed. The resulting solid was recrystallized from hexane to obtain 0.33 g of the title compound as yellowish white powder.

Provenance & Evidence