Hydrochloric Acid → HCID 178527574, compound

Participants

Reaction Conditions

Reaction Steps

0.89 g of 11-[2-(4-cyanophenylsulfonylamino)ethylthio]-2-(quinolin-2-yl)methoxy-6,11-dihydrodibenz[b,e]oxepine obtained in Example 34, 0.29 g of sodium azide and 0.24 g of ammonium chloride suspended in 5 ml of dimethylformamide were stirred at 120° C. for 1 hour. The reaction mixture was added to ice water and adjusted to about pH 3 with 1N-hydrochloric acid. Crystals precipitated were collected by filtration, dried and then washed with methylene chloride to obtain 0.69 g of the title compound as slightly yellow powder.

Provenance & Evidence