Pyridine → Methyl 2-chloro-3-(2,6-difluorophenylsulfonamido)benzoate

HRID 2328596Notes

Reaction equation

HRID 2328596 reaction equation
[Cl:1][c:2]1[n:3][c:4]([CH:5]=[C:6]([c:7]2[cH:8][c:9]([NH:10][S:18](=[O:19])(=[O:20])[c:21]3[c:22]([F:28])[cH:23][cH:24][cH:25][c:26]3[F:27])[cH:11][cH:12][cH:13]2)[OH:14])[cH:15][cH:16][n:17]1.[Cl:59][CH2:60][Cl:61].[F:47][c:48]1[cH:49][cH:50][cH:51][c:52]([F:53])[c:54]1[S:55]([Cl:56])(=[O:57])=[O:58].[NH2:29][c:30]1[c:31]([Cl:40])[c:32]([C:33](=[O:34])[O:35][CH3:36])[cH:37][cH:38][cH:39]1.[cH:41]1[cH:42][cH:43][n:44][cH:45][cH:46]1>>[S:18](=[O:19])(=[O:20])([c:21]1[c:22]([F:28])[cH:23][cH:24][cH:25][c:26]1[F:27])[NH:29][c:30]1[c:31]([Cl:40])[c:32]([C:33](=[O:34])[O:35][CH3:36])[cH:37][cH:38][cH:39]1

Participants

6

Reactant 5

HCID 1049PyridineHCID 6344DichloromethaneHCID 27342712,6-Difluorobenzenesulfonyl chlorideHCID 15132848Methyl 3-amino-2-chlorobenzoateHCID 154041434N-[3-[2-(2-chloropyrimidin-4-yl)-1-hydroxyethenyl]phenyl]-2,6-difluorobenzenesulfonamide

Product 1

HCID 57989637Methyl 2-chloro-3-(2,6-difluorophenylsulfonamido)benzoate

Sources & evidence

ORD record
ord-179c077d04624341bbf4d7e6e9d58d86
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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