反应详情

3 g of sodium boron hydride was added to 11.19 g of 7-chloro-6-fluoro-2-formylquinoline obtained in Reference example 2 suspended in 250 ml of methanol and the mixture was stirred at room temperature for 1 hour. After the solvent was removed, the residue was extracted with ice water-methylene chloride and the organic layer was washed with water and dried over anhydrous sodium sulfate. After the solvent was removed, the residue was applied to silica gel column chromatography to obtain 7.84 g of the title compound.

1. customobtained in Reference example 2
2. customAfter the solvent was removed
3. extractionthe residue was extracted with ice water-methylene chloride
4. washthe organic layer was washed with water
5. dry with materialdried over anhydrous sodium sulfate
6. customAfter the solvent was removed