Sodium Hydroxide → HCID 23359124, compound

Participants

Reaction Steps

6 ml of a 3N-sodium hydroxide aqueous solution was added to 2.8 g of 2-acetoxy-8-cyano-11-oxo-6,11-dihydrodibenz[b,e]oxepine obtained in Reference example 25 dissolved in 30 ml of methanol and the mixture was stirred at room temperature for 3 hours. After completion of the reaction, the solvent was removed under reduced pressure, water was added to the residue and the mixture was adjusted to about pH 2 with conc. hydrochloric acid. Crystals precipitated were collected by filtration and dissolved in ethyl acetate and the organic layer was washed with a saturated saline solution and then dried over anhydrous sodium sulfate. The solvent was removed from the solution to obtain 2.35 g of the title compound.

Provenance & Evidence