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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 232877Generated: October 25, 2026

Ethanethiol → 2-(7-Chloro-6-ethylthioquinolin-2-yl)methoxy-11-oxo-6,11-dihydrodibenz[b,e]oxepine

https://huagongshe.com/reaction/232877

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthanethiolHCID 6343—
ReactantPotassium CarbonateHCID 11430—
Reactant2-(7-Chloro-6-fluoroquinolin-2-yl)methoxy-11-oxo-6,11-dihydrodibenz[b,e]oxepineHCID 23359142—
SolventDimethylformamideHCID 6228—
Product2-(7-Chloro-6-ethylthioquinolin-2-yl)methoxy-11-oxo-6,11-dihydrodibenz[b,e]oxepineHCID 23359231—

Reaction Conditions

Temperature90 °C

Reaction Steps

0.37 ml of ethyl mercaptan and 1.12 g of potassium carbonate were added to 2.0 g of 2-(7-chloro-6-fluoroquinolin-2-yl)methoxy-11-oxo-6,11-dihydrodibenz[b,e]oxepine dissolved in 80 ml of dimethylformamide and the mixture was stirred at 90° C. for 4 hours.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05591752
Source datasetuspto-grants-1997_01
ORD IDord-173c904036b3494ca7a6e3278b1b792f
Source noteuspto-grants-1997_01