Potassium Hydroxide → HCID 23361041, compound

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (114 mg, 3 mmol) and aluminum chloride (400 mg, 3 mmol) in ether (5 ml), a suspension of 1'-methylspiro[tetralin-2,3'-piperazine]-2',5'-dione (80 mg, 0.33 mmol) in ether (2 ml) was added, while the former was stirred under ice cooling conditions, followed by further stirring at room temperature for 10 minutes. After a 1N aqueous potassium hydroxide solution was added, the precipitate was filtered off. The filtrate was washed by sequential additions of a 1 N aqueous potassium hydroxide solution and chloroform. After the mother liquor was eluted with saturated saline, the organic layer was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to yield the title compound (50 mg, 70%) as an oil.

Provenance & Evidence