HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (S)-N1-((2,3-Dihydroxy)propyl)cytosine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (+)-Glycidol | HCID 5460455 | — |
| Reactant | Cytosine | HCID 178418229 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (S)-N1-((2,3-Dihydroxy)propyl)cytosine | HCID 11805434 | 43.1% |
Reaction Steps
Reaction of cytosine (2.2 g, 19.8 mmol) with (R)-glycidol (88% ee, 1.51 ml, 22.8 mmol) in the presence of anhydrous potassium carbonate (40 mg, 0.289 mmol) in dry DMF (20 ml) at 72° C. for 5 hours, as described in Example 1, furnished the title compound (88% ee) in 43.1% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05591852 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-0d91becee4f14c64a252fcb6929bd28f |
| Source note | uspto-grants-1997_01 |