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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 232908Generated: October 25, 2026

Cidofovir → [(2R)-1-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid

https://huagongshe.com/reaction/232908

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCidofovirHCID 60613—
Reactant(-)-GlycidolHCID 6973630—
ReactantHCID 178522337HCID 178522337—
Product[(2R)-1-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acidHCID 513605—

Reaction Steps

The title compound (R)-HPMPC was prepared from (S)-glycidol (88% ee) and N4 -benzoylcytosine, following the method described for (S)-HPMPC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05591852
Source datasetuspto-grants-1997_01
ORD IDord-bfc1ba919bfc4fa29b2b10f0b66d2b44
Source noteuspto-grants-1997_01